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Can the particle size of barium sulfate affect its use in the pharmaceutical industry?
- 2019-11-28-

Barium sulfate has been used in medicine and industry for many years, but in recent years, due to the development of the pigment, paper, and rubber industries, fine and uniform barium sulfate is required as an auxiliary or additive, and the development of X-ray two-layer imaging skills requires more fine and uniform Barium sulfate. Therefore, many domestic research and production enterprises have discussed the process of preparing fine barium sulfate and reached the expected requirements. Now, we at Gongyi Best Environmental Protection Materials Co., Ltd. have integrated the results of several discussions as follows, hoping to help friends in need. Briefly introduce the process of producing fine particles of barium sulfate

1: Dissolve and refine sodium chloride with a barium chloride content of more than 98%, add 10 times water according to the amount, heat to dissolve, filter, take the filtrate, adjust the pH to 2-3 with hydrochloric acid, add an appropriate amount of sodium hypochlorite, and heat To boil, boil for half an hour to remove the sulfide, check the sulfide with aluminum acetate cotton to a qualified stop, stop for more than 8 hours, filter, remove the filter residue, and use the filtrate for backup.

2: For the dissolution and purification of sodium sulfate, use sodium sulfate with a content of more than 98%, add 10 times water according to the amount, heat to dissolve, filter, take the filtrate, adjust the pH to 3-4 with sulfuric acid, add a small amount of sodium hypochlorite, and heat to boiling , Boil for half an hour, remove the sulfide. Use aluminum acetate cotton to check the sulfide until it is qualified to stop. Let it stand for more than 8 hours, filter, remove the filter residue, and use the filtrate for backup.

3: The combination of fine barium sulfate is to take the refined barium chloride solution into the reaction tank first, and then slowly and uniformly participate in the sodium sulfate solution under mixing. The reaction temperature is controlled at 60-70 ° C, and a slight excess of sodium sulfate is added to Contains soluble barium salts at the end. Discontinue Chen Hua for more than 8 hours. Suction filtration until the moisture content is about 35% is thick white barium sulfate. The test is qualified. It is ready for the preparation of X-ray two-layer contrast barium sulfate.

Conditions for controlling the size of barium sulfate particles. Barium sulfate for medical use is used in X-ray two-layer radiography. It is necessary to have small and uniform particles. Generally, the particle size is less than 3 meshes. It is easy to adhere to the mucosal wall. , And easy to show stomach area. However, the particle size of commercially available barium sulfate varies greatly, the larger one is larger than 50 mesh, and the smaller one can be less than 0.1 mesh. Too large particles have the following defects: affecting the degree of looseness, rapid sedimentation, fast movement, uneven distribution, and resulting in uneven coating of the mucosa, which is not conducive to the accuracy of early diagnosis and diagnosis of the lesion. If the particle size of barium sulfate used in medicine is too small, it is easy to "clump" in gastric juice, and the anti-coagulation is not good, which affects the accuracy of imaging and diagnosis. Therefore, the size of barium sulfate particles is directly related to the quality of the contrast.

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